Difference between revisions of "Corona Detective"
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This last pandemic year has brought together a lot of open collaborative research, including... | This last pandemic year has brought together a lot of open collaborative research, including... | ||
[[File:CoronaDetectiveLogo.png|300px|thumb|]] | [[File:CoronaDetectiveLogo.png|300px|thumb|]] | ||
| − | + | '''The Corona Detective Project''' | |
| − | [[File:Charla-rachel-2-final.jpg|thumb]] | + | [[File:Charla-rachel-2-final.jpg|thumb]] |
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Here is our recent [[:File:SimplerOnePager Accurate Inexpensive Covid 19 Testing for Low Resource Settings.pdf|simple one page summary]] to seek more partners to help get this out where it is needed most! | Here is our recent [[:File:SimplerOnePager Accurate Inexpensive Covid 19 Testing for Low Resource Settings.pdf|simple one page summary]] to seek more partners to help get this out where it is needed most! | ||
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<br> | <br> | ||
| − | == Introduction == | + | ==Introduction== |
This wiki page is under construction, to provide more information about this method for surveillance testing! | This wiki page is under construction, to provide more information about this method for surveillance testing! | ||
| − | === Context === | + | ===Context=== |
When the pandemic began, RA (as CSO of AGiR!) of course began some corona virus 'sequence gazing' ... | When the pandemic began, RA (as CSO of AGiR!) of course began some corona virus 'sequence gazing' ... | ||
Thomas Landrain's visit to Hackuarium was put off by 'lockdown' - but a big collaboration developed in the platform of his Just One Giant Lab (JOGL). | Thomas Landrain's visit to Hackuarium was put off by 'lockdown' - but a big collaboration developed in the platform of his Just One Giant Lab (JOGL). | ||
| − | RA got Guy and Fran in too, and one thing led to another... Here is our [https://www.youtube.com/watch?v=Tdfws3g3R2s 'teaser' video] from when we were semi-finalists for the xprize! | + | RA got Guy and Fran in too, and one thing led to another... Here is our [https://www.youtube.com/watch?v=Tdfws3g3R2s 'teaser' video] from when we were semi-finalists for the xprize! |
| + | |||
| + | The first 'workshop' of this [https://app.jogl.io/project/181/coronadetective method to detect the virus] causing Covid-19, inspired by the [https://gmodetective.com/ GMO Detective], was held on the evening of 9June21, and was virtual, as part of the [https://bbkopenscience.com/streaming/ BBK open science festival]!<br> | ||
| + | We had 4 labs (here, in Paris, in Bilbao, and in Zurich) running tests that day. <br>Happily, all 4 cities had great positive control results and no people positive... whew. (hope for video stream link ...) | ||
| + | |||
| + | The latest [http://wiki.hackuarium.ch/w/File:CoronaDetective_simpleUSERprotocol.pdf 'simple' protocol is available here], and your input is welcome.<br> | ||
| + | Versions in [https://drive.google.com/file/d/1dh8CtQ7T2gQDi0DfiUOVVBhu_V2wJViS/view?usp=sharing French] and [https://drive.google.com/file/d/1C6MxYRJEE3w7GJvJwHqevOMWM-C734HL/view?usp=sharing Spanish] are available too, already! | ||
| + | |||
| + | With our Colombian colleagues we also discussed the method virtually also, as the 2nd of a 3-part series of talks (Oct2020, as announced in the flyer, Charla #2). | ||
| − | === People === | + | === People=== |
'''Contact and lead:''' | '''Contact and lead:''' | ||
*Rachel Aronoff - Founder and CSO of AGiR! Action for Genomic integrity through Research! | *Rachel Aronoff - Founder and CSO of AGiR! Action for Genomic integrity through Research! | ||
'''Participants:''' | '''Participants:''' | ||
| − | * Tatiana Eliseeva | + | *Tatiana Eliseeva |
| − | * Guy Aidelberg | + | *Guy Aidelberg |
| − | * Fran Quero | + | *Fran Quero |
| − | * the whole JOGL 'project nucleic amplification team' and Thomas Landrain for support! | + | *the whole JOGL 'project nucleic amplification team' and Thomas Landrain for support! |
| − | * you? | + | *you? |
| − | === Main Goals === | + | ===Main Goals === |
Surveillance screening for Covid-19 | Surveillance screening for Covid-19 | ||
| − | === Objectives === | + | ===Objectives=== |
| − | *open science collaboration to develop a sensitive molecular diagnostic method | + | * open science collaboration to develop a sensitive molecular diagnostic method |
*testing and validation | *testing and validation | ||
*manufacturing at scale, to obtain regulator approval for surveillance screening (also of those with no symptoms) | *manufacturing at scale, to obtain regulator approval for surveillance screening (also of those with no symptoms) | ||
| − | == Recommendation + next steps == | + | ==Recommendation + next steps == |
| − | licensing agreements are needed | + | organising reliable GMP batches for independent validation by regulators has been a great difficulty, with it being hard to reach agreements at such a distance with no actual meetings. Additionally, it seems likely that licensing agreements are needed, as not only did extension of LAMP patent get approved, but there is a patent for the QUASR detection method depicted above (from the Sandia national labs in the states...). |
| + | Currently, we are in discussion with people in Ghana as those moronic variants get spread... (yes, sorry, sometimes only humor can help us realise - if people already knew more when this started and were strict the first 2 months, we might not be here 2 years later! -almost, yes...) | ||
[[Category:Work In Progress]] | [[Category:Work In Progress]] | ||
[[Category:Manual]] | [[Category:Manual]] | ||
Revision as of 20:05, 16 December 2021
This last pandemic year has brought together a lot of open collaborative research, including...
The Corona Detective Project
Here is our recent simple one page summary to seek more partners to help get this out where it is needed most!
We have a new graphic to explain how the 'quenched fluorescence' detection method works.
Introduction
This wiki page is under construction, to provide more information about this method for surveillance testing!
Context
When the pandemic began, RA (as CSO of AGiR!) of course began some corona virus 'sequence gazing' ... Thomas Landrain's visit to Hackuarium was put off by 'lockdown' - but a big collaboration developed in the platform of his Just One Giant Lab (JOGL). RA got Guy and Fran in too, and one thing led to another... Here is our 'teaser' video from when we were semi-finalists for the xprize!
The first 'workshop' of this method to detect the virus causing Covid-19, inspired by the GMO Detective, was held on the evening of 9June21, and was virtual, as part of the BBK open science festival!
We had 4 labs (here, in Paris, in Bilbao, and in Zurich) running tests that day.
Happily, all 4 cities had great positive control results and no people positive... whew. (hope for video stream link ...)
The latest 'simple' protocol is available here, and your input is welcome.
Versions in French and Spanish are available too, already!
With our Colombian colleagues we also discussed the method virtually also, as the 2nd of a 3-part series of talks (Oct2020, as announced in the flyer, Charla #2).
People
Contact and lead:
- Rachel Aronoff - Founder and CSO of AGiR! Action for Genomic integrity through Research!
Participants:
- Tatiana Eliseeva
- Guy Aidelberg
- Fran Quero
- the whole JOGL 'project nucleic amplification team' and Thomas Landrain for support!
- you?
Main Goals
Surveillance screening for Covid-19
Objectives
- open science collaboration to develop a sensitive molecular diagnostic method
- testing and validation
- manufacturing at scale, to obtain regulator approval for surveillance screening (also of those with no symptoms)
Recommendation + next steps
organising reliable GMP batches for independent validation by regulators has been a great difficulty, with it being hard to reach agreements at such a distance with no actual meetings. Additionally, it seems likely that licensing agreements are needed, as not only did extension of LAMP patent get approved, but there is a patent for the QUASR detection method depicted above (from the Sandia national labs in the states...).
Currently, we are in discussion with people in Ghana as those moronic variants get spread... (yes, sorry, sometimes only humor can help us realise - if people already knew more when this started and were strict the first 2 months, we might not be here 2 years later! -almost, yes...)