Corona Detective

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(française dessous)

This last pandemic year has brought together a lot of open collaborative research, including...

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The Corona Detective Project

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Here is our recent simple one page summary to seek more partners to help get this out where it is needed most!

We have a new graphic, QuasrGraphic3 (below right), to explain how the amazing 'quenched fluorescence' detection method works, which provides such clear positive and negative endpoint results in Corona Detective reactions.

Because we have focussed on open science and securing GMP 'at scale' production, and not made a company directly, people are not sure how to deal with us, perhaps to the project's detriment. One international colleague first asked to license our open protocols, and most recently was asking for our recommendations for a lyophiliser. =)

(this colleague is helping fill the 1h test result market for 200 bucks a pop... )

Possibly we should have just gone to the Swiss regulators early on, with reaction tubes freeze-dried at CRI.

XPRIZE, outside of getting us more control results (other viruses, too) was basically only fun...

but again this is because our 'business model' is inexistant. LOL

maybe you could help?

Le lien au dessus va vers notre récent et simple résumé d'une page pour rechercher d'autres partenaires afin d'aider à diffuser ce produit là où il est le plus nécessaire !

Nous avons créé un nouveau graphique, QuasrGraphic3 (en bas à droite), pour expliquer le fonctionnement de l'étonnante méthode de détection par "fluorescence éteinte", qui fournit des résultats positifs et négatifs si clairs dans les réactions du Détective de Corona.

Parce que nous nous sommes concentrés sur la science ouverte et sur l'assurance d'une production GMP "à l'échelle", et que nous n'avons pas créé directement une entreprise, les gens ne savent pas comment traiter avec nous, peut-être au détriment du projet.

Par exemple, un collègue international a d'abord demandé une licence pour nos protocoles ouverts et, plus récemment, il nous a demandé nos recommandations pour un lyophilisateur. =)

(ce collègue contribue à remplir le marché des résultats de tests en une heure pour 200 dollars la pièce...)


Nous aurions peut-être dû, dès le début, nous en remettre nos réactifs aux régulateurs suisses, avec des tubes de réaction lyophilisés au CRI.

XPRIZE, en dehors du fait qu'il nous a permis d'obtenir plus de résultats de contrôle (d'autres virus aussi), n'était fondamentalement qu'un amusement...

mais encore une fois, c'est parce que notre "modèle économique" est inexistant. LOL

Vous pourriez peut-être nous aider ?


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Introduction

This wiki page is under construction, to provide more information about this method for surveillance testing!

Context

When the pandemic began, RA (as CSO of AGiR!) of course began some corona virus 'sequence gazing' ... Thomas Landrain's visit to Hackuarium was put off by 'lockdown' - but a big collaboration developed in the platform of his Just One Giant Lab (JOGL). RA got Guy and Fran in too, and one thing led to another... Here is our 'teaser' video from when we were semi-finalists for the xprize!

The first 'workshop' of this method to detect the virus causing Covid-19, inspired by the GMO Detective, was held on the evening of 9June21, and was virtual, as part of the BBK open science festival!
We had 4 labs (here, in Paris, in Bilbao, and in Zurich) running tests that day.
Happily, all 4 cities had great positive control results and no people positive... whew. (hope for video stream link ...)

The latest 'simple' protocol is available here, and your input is welcome.
Versions in French and Spanish are available too, already!

With our Colombian colleagues we also discussed the method virtually also, as the 2nd of a 3-part series of talks (Oct2020, as announced in the flyer, Charla #2).

People

Contact and lead:

  • Rachel Aronoff - Founder and CSO of AGiR! Action for Genomic integrity through Research!

Participants:

  • Tatiana Eliseeva
  • Guy Aidelberg
  • Fran Quero
  • the whole JOGL 'project nucleic amplification team' and Thomas Landrain for support!
  • you?


Main Goals

Surveillance screening for Covid-19

Objectives

  • open science collaboration to develop a sensitive molecular diagnostic method
  • testing and validation
  • manufacturing at scale, to obtain regulator approval for surveillance screening (also of those with no symptoms)

Recommendation + next steps

organising reliable GMP batches for independent validation by regulators has been a great difficulty, with it being hard to reach agreements at such a distance with no actual meetings. Additionally, it seems likely that licensing agreements are needed, as not only did extension of LAMP patent get approved, but there is a patent for the QUASR detection method depicted above (from the Sandia national labs in the states...).

Currently, we are in discussion with people in Ghana as those moronic variants get spread... (yes, sorry, sometimes only humor can help us realise - if people already knew more when this started and were strict the first 2 months, we might not be here 2 years later! -almost, yes...)